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or a pharmaceutically acceptable salt thereof, wherein X is N or C R 3; R 1 is R, R D, or OR; R 2 is H, R C, N R C O Cy 2, N R S O 2 Cy 2, N R Cy 2, OCy 2, SCy 2, or Cy 2; R 3 is H, halogen, or C 1 6 aliphatic; or R 2 and R 3 are taken together with their intervening atoms to form a 4 7 membered partially unsaturated or aromatic ring having 0 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur; wherein said ring is substituted with m instances of R 4; each of Cy 1 and Cy 2 is independently phenyl; a 5 6 membered monocyclic heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; an 8 10 membered bicyclic heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 3 7 membered saturated or partially unsaturated heterocyclic ring having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or a 3 7 membered saturated or partially unsaturated monocyclic carbocyclic ring; or a 7 12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, wherein Cy 1 is substituted with n instances of R 5; and; wherein Cy 2 is substituted with p instances of R 6; L 1 is a covalent bond or a C 1 4 bivalent saturated or unsaturated, straight or branched hydrocarbon chain wherein one or two methylene units of the chain are optionally and independently replaced by C R 7 2, N R, N R C O, C O N R, N R S O 2, S O 2 N R, O, C O, OC O, C O O, S, S O or S O 2; each instance of R 4, R 5, R 6, and R 7 is independently R A or R B, and is substituted by q instances of R C; each instance of R A is independently oxo, halogen, CN, NO 2, OR, OR D, SR, NR 2, S O 2 R, S O 2 NR 2, S O R, S O NR 2, C O R, C O OR, C O NR 2, C O N R OR, OC O R, OC O NR 2, N R C O OR, N R C O R, N R C O NR 2, N R C NR NR 2, N R S O 2 NR 2, or N R S O 2 R; each instance of R B is independently C 1 6 aliphatic; phenyl; a 5 6 membered monocyclic heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; an 8 10 membered bicyclic heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 3 7 membered saturated or partially unsaturated carbocyclic ring; a 3 7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or a 7 12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; each instance of R C is independently oxo, halogen, CN, NO 2, OR, SR, NR 2, S O 2 R, S O 2 NR 2, S O R, S O NR 2, C O R, C O OR, C O NR 2, C O N R OR, OC O R, OC O NR 2, N R C O OR, N R C O R, N R C O NR 2, N R C NR NR 2, N R S O 2 NR 2, or N R S O 2 R or an optionally substituted group selected from C 1 6 aliphatic, phenyl, a 3 7 membered saturated or partially unsaturated heterocyclic ring having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5 6 membered heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; R D is a C 1 4 aliphatic group wherein one or more hydrogens are replaced by deuterium; each R is independently hydrogen, or an optionally substituted group selected from C 1 6 aliphatic, phenyl, a 3 7 membered saturated or partially unsaturated heterocyclic having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5 6 membered heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or two R groups on the same nitrogen are taken together with their intervening atoms to form a 4 7 membered saturated, partially unsaturated, or heteroaryl ring having 0 3 heteroatoms, in addition to the nitrogen, independently selected from nitrogen, oxygen, and sulfur; and each of m, n, p, and q is independently 0, 1, 2, 3, or 4 <a href=https://acialis.mom>buy cialis online without prescription</a> Open lung biopsy via thoracotomy was popularized in the 1960s 19